Zhang, Wei,Flemming, Michael S.,Amphlett, Godfrey,Chih, Hung-Wei,Bartlett, Elizabeth
申请号：
AU2012211479
公开号：
AU2012211479A1
申请日:
2012.08.10
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2012211479A120120830.pdf#####ABSTRACT The present invention provides an immunoconjugate formulation that is substantially free of particles, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of: sucrose, polysorbate 20, polysorbate 80, cyclodextrin, dextrose, glycerol, polyethylene glycol, mannitol, sodium chloride, and an amino acid, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention also provides an immunoconjugate formulation that is substantially free of aggregates, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of histidine, sucrose, glycine and sodium chloride, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention further provides an immunoconjugate formulation that is substantially free of both particles and aggregates. 3597410_1 (GHMatters) P76423AU.1
