ZHANG WEI,FLEMING MICHAEL S,AMPHLETT GODFREY,CHIH HUNG-WEI,BARTLETT ELIZABETH
申请号：
NZ59917606
公开号：
NZ599176A
申请日:
2006.08.02
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
599176 Disclosed is an immunoconjugate formulation that is substantially free of particles, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of: sucrose, polysorbate 20, polysorbate 80, cyclodextrin, dextrose, glycerol, polyethylene glycol, mannitol, sodium chloride, and an amino acid, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention also provides an immunoconjugate formulation that is substantially free of aggregates, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of histidine, sucrose, glycine and sodium chloride, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. In one embodiment the immunoconjugate comprises an antibody covalently linked to a maytansinoid.
