BARANOWSKI, Andreas,ROMMENS, Pol Maria,RITZ, Ulrike,KLEIN, Anja,HOFMANN, Alexander,ARMBRUSTER, Franz Paul
申请号：
EP17166712.4
公开号：
EP3231453B1
申请日:
2017.04.14
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
Structurally strong bone replacement body of mineral calcium phosphate cement with remaining hydraulic activity, containing in a proportion of Tied off calcium phosphate mineral cement and a proportion of non-Tied off hydraulically reactive calcium phosphate cement, characterized in that the bone substitute body of cement strands is constructed with interconnecting pores that according to the configuration, a step with hydraulic setting and hardening of the strands follows, and that applied to the hydraulically set, hardened surface and in the pores of said replacement body, which is substantially inert towards proteins now, by Physissorption human bone sialoprotein. Characterized the human bone sialoprotein is a bioactive non-collagenes bone matrix protein which promotes the differentiation of mesenchymal stem cells into osteoblasts and osteoclasts, which are needed for new bone formation and bone turnover.
