The process comprises detecting pills (2) taken by a patient (3) using a platelet (4) of an electronic circuit (5) for detection and recording the time of extraction of pills belonging to a blister (6), transmitting electrical radio signals from the circuit in real time, capturing and measuring the signals that are transferred in real time or near real time to a remote server to create a data file of observance associated to the patient, and processing the observation data to monitor, improve and/or modify the monitoring of treatment by the patient. The process comprises detecting pills (2) taken by a patient (3) using a platelet (4) of an electronic circuit (5) for detection and recording the time of extraction of pills belonging to a blister (6), transmitting electrical radio signals from the circuit in real time, capturing and measuring the signals that are transferred in real time or near real time to a remote server to create a data file of observance associated to the patient, and processing the observation data to monitor, improve and/or modify the monitoring of treatment by the patient. The platelet is formed of a flexible support on which a part of conductor circuit is printed for forming open interrupters when the pills are manually extracted by the user after adhesion of blister on the platelet. The signals are collected from a telephone connected directly or indirectly to Internet network. The observation data is automatically processed from a control algorithm that determines and transmits it in real time or near real time. The transmitted signals are retransmitted by a text message or telephone call to undertake actions for the patient automatically. Impedance is regularly tested, for detecting positive or negative error, by periodically measuring the voltage and obtaining an average value from 5-10 measurements, comparing the obtained results with the predetermined value, and extracting the pills if the obtained value is greater than a predetermined v
