System and method for related with polymer foam is generally described. Some embodiments are related to composition and method is used to prepare polymer foam, the method for using polymer foam. Polymer foam can be applied to a body cavity and be placed on in the contacting of such as tissue, injured tissue, internal organs etc.. In some embodiments, polymer foam can be formed in a body cavity (that is, blistering in situ). In addition, foamed polymer can apply the pressure to an inner surface of a body cavity and prevent or the limitation of body fluid (for example, blood etc.) movement.