Langston, Steven P.,Olhava, Edward J.,Vyskocil, Stepan,LANGSTON STEVEN P,LANGSTON, STEVEN P.,OLHAVA EDWARD J,OLHAVA, EDWARD J.,VYSKOCIL STEPAN,VYSKOCIL, STEPAN
申请号：
ES11166220
公开号：
ES2593433T3
申请日:
2007.01.31
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of the formula (I): ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: the stereochemical configurations represented at the positions marked with an asterisk indicate relative stereochemistry； Ring A is: ** Formula ** or ** Formula ** where a ring nitrogen atom in Ring A is optionally oxidized X is -CH2-, -CHF, -CF2, -NH, or -O- ； Y is -O-, -S-, or -C (Rm) (Rn) -； Ra is hydrogen, fluoro, -OH, -OCH3 or CH3； or Ra and Rc together form a bond； Rb is hydrogen, fluoro, C1-4 aliphatic, or C1-4 fluoroaliphatic； Rc is hydrogen, fluoro or -OR5； or Rc and Ra together form a bond； Rd is hydrogen, fluoro, C1-4 aliphatic, or C1-4 fluoroaliphatic； Re is hydrogen, or C1-4 aliphatic； Re 'is hydrogen or C1-4 aliphatic； each Rf is independently hydrogen or aliphatic C1-4； Rg is hydrogen, C1-6 aliphatic, C1-6 fluoroaliphatic, halo, -R1g, -R2g, -T1-R1g, -T1-R2g, -V1-T1-R1g, or -V1-T1-R2g； T1 is a C1-6 alkylene chain substituted with 0-2 R3a or R3b independently selected, wherein the alkylene chain is optionally interrupted by -C (R5)>； = C (R5) -, -C>； = C-, -O -, -S-, - S (O) -, -S (O) 2-, -SO2N (R4) -, -N (R4) -, -N (R4) C (O) -, -NR4C (O ) N (R4) -, -N (R4) C (>； = NR4) -N (R4) -, - N (R4) -C (>； = NR4) -, -N (R4) CO2-, -N ( R4) SO2-, -N (R4) SO2N (R4) -, -OC (O) -, -OC (O) N (R4) -, -C (O) -, - CO2-, -C (O) N (R4) -, -C (>； = NR4) -N (R4) -, -C (NR4)>； = N (R4) -, -C (>； = NR4) -O-, or -C (R6) >； = NO-, and where T1 or a portion thereof is optionally part of a 3-7 member ring； V1 is -C (R5)>； = C (R5) -, -C≡C-, -O-, -S-, -S (O) -, -S (O) 2-, -SO2N (R4) - , -N (R4) -, -N (R4) C (O) -, - NR4C (O) N (R4) -, -N (R4) C (>； = NR4) -N (R4) -, -N (R4) C (>； = NR4) -, -N (R4) CO2-, -N (R4) SO2-, - N (R4) SO2N (R4) -, -OC (O) -, -OC (O) N (R4) -, -C (O) -, -CO2-, -C (O) N (R4) -, -C (O) N (R4) -O-, - C (O) N (R4) C (>； = NR4) -N (R4) -, -N (R4) C (>； = NR4) -N (R4) -C (O) -, -C (>； = NR4) -N (R4) -, -C (NR4)>； = N (R4) -, - C (>；
