Generally speaking, it is the composition and method of treating cancer and new shape diseases. Alternative pyridine derivatives and pharmaceutical ingredients containing such compounds are listed in this table. The compounds and compounds used can be used to inhibit hysterisis. In addition, target compounds and ingredients are also helpful in the treatment of cancers such as prostate, breast, bladder, lung and / or melanoma. 1. Characteristic 1: a compound or its stereoisomer or a salt acceptable for medicine,1. Adopt the structure of formula (1), where x is o or ch832222；R⁶ is selected from optionally substituted heterocyclyl, optionally substituted heterocyclyloxy, optionally substituted heterocyclylalkyl, optionally substituted heterocyclyl alkoxy, optionally substituted aryl C₆₋₁₀-SO₂-, optionally substituted heteroaryl-S- or -N (R¹) (R²),wherein R¹ is hydrogen or optionally substituted alkyl and R² is selected from optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl-CO-alkyl, heteroaryl-CO-optionally substituted, cycloalkyl-CO- optionally substituted or alkyl-CO- optionally substituted； and every R⁵,R⁷ and R⁸ are independently selected from hydrogen, halogen, -OH, -CN, optionally substituted C₁₋₆ alkyl, optionally substituted C alco alkoxy, optionally substituted C₃₋₇ carbocyclyl, optionally substituted C carbo carbocyclyloxy, carbocyclylalkyl Optionally substituted C₄₋₁₂, optionally substituted carbocyclylalkoxy Cco, optionally substituted C₁₋₆ alkynyl, optionally substituted Cque alkenyl, optionally substituted C₆₋₁₀ aryl, optionally substituted C₆₋₁₀-oxy aryl, C₆₋₁₀-S- aryl optionally substituted, optionally substituted aralkoxy Cxi,optionally substituted heteroaryl and optionally substituted heteroaryloxy, optionally substituted heterocyclyl, optionally substituted heterocyclyl
