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Apoptosis signal-regulating kinase inhibitor
专利权人:
GILEAD SCIENCES INC.
发明人:
Notte, Gregory
申请号:
NZ73933913
公开号:
NZ739339A
申请日:
2013.01.24
申请国别(地区):
NZ
年份:
2019
代理人:
摘要:
Disclosed is a tablet comprising selonsertib (5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide) and its use as an apoptosis signal-regulating kinase inhibitor for the treatment of kidney fibrosis, liver fibrosis, lung fibrosis, diabetic nephropathy or diabetic kidney disease. Also disclosed are the two intermediates 5-(4-cyclopropy1-1H-imidazol-1-y1)-2-fluoro-4-methylbenzoic acid and 6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-amine used in the preparation of said compound Selonsertib.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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