DORONINA, SVETLANA O.,SENTER, PETER D.,TOKI, BRIAN E.,EBENS, ALLEN J.,KLINE, TONI BETH,POLAKIS, PAUL,SLIWKOWSKI, MARK X.,SPENCER, SUSAN D.
申请号：
CA2841741
公开号：
CA2841741C
申请日:
2004.11.05
申请国别(地区):
CA
年份:
2020
代理人:
摘要：
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal- Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
