PROTOZOAIRE MODIFIE EXPRIMANT AU MOINS DEUX PROTEINES DE SURFACE VARIABLES (VSP), VACCIN LE COMPRENANT ET PROTOCOLES, UTILISATIONS ET PROCEDES ASSOCIES
CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET);UNIVERSIDAD CATOLICA DE CORDOBA
发明人:
LUJAN, HUGO DANIEL
申请号：
CA2745470
公开号：
CA2745470C
申请日:
2009.12.02
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Modified protozoa parasitescomprising simultaneous expression on its surfaceof at least two variable surface proteins(VSP). The modified protozoa may also simultaneouslyexpress the complete repertoire ofvariable surface proteins. Protozoa show reducedexpression of Dicer, RNA-dependantRNA-polymerase (RdRP) enzymes or both,wherein the RdRP gene and/or the Dicer genehas been silenced. The protozoan may be anyprotozoan showing an antigenic variationmechanism.
