PROTOZOAIRE MODIFIÉ EXPRIMANT AU MOINS DEUX PROTÉINES DE SURFACE VARIABLES (VSP), VACCIN LE COMPRENANT ET PROTOCOLES, UTILISATIONS ET PROCÉDÉS ASSOCIÉS
Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Conicet);Universidad Católica de Córdoba (UCC)
发明人:
申请号：
EP09799724.1
公开号：
EP2364156B1
申请日:
2009.12.02
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Modified protozoa parasites comprising simultaneous expression on its surface of at least two variable surface proteins (VSP). The modified protozoa may also simultaneously express the complete repertoire of variable surface proteins. Protozoa show reduced expression of Dicer, RNA-dependant RNA-polymerase (RdRP) enzymes or both, wherein the RdRP gene and/or the Dicer gene has been silenced. The protozoan may be any protozoan showing an antigenic variation mechanism.
