Proteogenomics Research Institute for Systems Medicine
发明人:
Jan E. SCHNITZER,Philip Sung-Whan OH,Adrian CHRASTINA,Michael D. LEVIN,Bogdan Z. OLENYUK,Rajesh KOTA
申请号：
US16699455
公开号：
US20200171165A1
申请日:
2019.11.29
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Methods and compositions for enhancing the therapeutic activity of agents at low doses as a result of improved targeted drug delivery, namely precision delivery, are described. The methods and compositions can be used to decrease the effective administered amounts of active therapeutic agents via precision delivery to targets capable of mediating active transport across the biological barrier formed by the vasculature that lines blood vessels. Antibodies (and other targeting agent species) to precisely deliver an active ingredient (i.e., a therapeutic agent) to cells expressing, for example, a target protein on their cell membranes, are also described, as are methods of treating disease.
