Crystalline forms of 5 - (4-morpholinyl 2.6 - Di - - 4 - pirimidinil) - trifluoro - 4 - methyl - 2 - pyridin - and Amine Salt monohydrochloride Pharmaceutical Composition and its use for the treatment of a proliferative disease as carcionoma Brain, Colon, Breast, Leukemia, Multiple Myeloma, carcionoma, entr And others.
CALIENNI, JOHN VINCENT,DE LA CRUZ, MARILYN,FLUBACHER, DIETMAR,GONG, BAOQING,KAPA, PRASAD KOTESWARA,KARPINSKI, PIOTR H.,LUI, HUI,MICHAEL, PASCAL,MOSE, RASMUS,TESTA, MARIA CATERINA,WAYKOLE, LILADHAR MUR
申请号：
CL2013000850
公开号：
CL2013000850A1
申请日:
2013.03.28
申请国别(地区):
CL
年份:
2013
代理人:
摘要：
The invention relates to processes for manufacturing a compound of formula 5, or a stereoisomer, tautomer or a salt thereof, wherein the substituents are as defined in the specification. The invention further relates to new manufacturing processes for specific solid forms of Compound A and its salts, to such solid forms and to use of said solid forms for the therapeutic treatment of warm-blooded animals.FORMAS CRISTALINAS DE 5-(2,6-DI-4-MORFOLINIL-4-PIRIMIDINIL)-4-TRIFLUORO-METIL-PIRIDIN-2-AMINA Y DE LA SAL MONOCLORHIDRATO COMPOSICION FARMACEUTICA； Y SU USO PARA EL TRATAMIENTO DE UNA ENFERMEDAD PROLIFERATIVA COMO CARCIONOMA DE CEREBRO, DE COLON, LEUCEMIA, MIELOMA MULTIPLE, CARCIONOMA MAMARIO, ENTRE OTROS.
