According to embodiments, a polymer, and a pharmaceutical composition employing the same are disclosed. The polymer includes a first repeating unit, a second repeating unit, and a third repeating unit. In particular, the first repeating unit is the second repeating unit is wherein R1 is C1-6 alkyl group and the third repeating unit is , wherein X is , or , and Y is a hydrophilic polymeric moiety.本發明提供一種聚合物、及包含其之醫藥組合物。根據本發明一實施例,該聚合物可例如為一改質之聚乙烯醇,包含一第一重複單元、一第二重複單元、以及一第三重複單元,其中該第一重複單元係;該第二重複單元係,其中R1係C1-6烷基;以及,該第三重複單元係為,其中X係、或,以及Y係親水性高分子基團。