Patrick CHUN;Keith W. ORFORD;Axel HOOS;GLAXOSMITHKLINE LLC;MERCK SHARP & DOHME CORP.;Venkatarama SRIRAM;Elaine M. PINHEIRO;Scot W. EBBINGHAUS
发明人:
Axel Hoos,Keith W. Orford,Patrick Chun,Venkataraman Sriram,Elaine M. Pinheiro,Scot W. Ebbinghaus
申请号：
US14893746
公开号：
US20160106835A1
申请日:
2014.05.28
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A novel combination comprising a B-Raf inhibitor, particularly N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethyl； -2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and a PD-1 antagonist； pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of MEK and/or B-Raf and/or immune modulation through PD-1 is beneficial, e.g., cancer.
