The present invention provides a use of composition containing ferrous amino acid chelate in manufacturing drug for ameliorating diabetes. The drug comprises an effective dosage of a composition containing a ferrous amino acid chelate for ameliorating diabetes and a pharmaceutically acceptable carrier thereof. In the disclosed composition containing the ferrous amino acid chelate, the amino acid and the Fe<2+> are maintained in a chelate state for passing through the stomach, so as to reduce blood sugar and promote susceptibility of insulin. The drug manufactured from the composition containing the ferrous amino acid chelate is characterized with an effect of ameliorating diabetes.本發明提供一種含有亞鐵胺基酸螯合物之組合物用於製造改善糖尿病之醫藥品的用途,其中醫藥品包含有效改善糖尿病劑量之含有亞鐵胺基酸螯合物之組合物以及其藥學上可接受的載劑。本發明所述之含有亞鐵胺基酸螯合物之組合物中,胺基酸可與亞鐵維持螯合狀態通過胃,且可降低血糖以及改善胰島素之感受性;本發明所述之含有亞鐵胺基酸螯合物之組合物製造而得之醫藥品具有改善糖尿病之效果。