Johann Wolfgang Goethe-Universität, Frankfurt Am Main;DRK BLUTSPENDEDIENST BADEN-WÜRTTEMBERG-HESSEN GGMBH
发明人:
Peter Bader,Selim Kuci,Zyrafete Kuci,Halvard Bönig
申请号：
US16586302
公开号：
US20200231935A1
申请日:
2019.09.27
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention pertains to an improved mesenchymal stromal cell (MSC) preparation and a method for producing the same. The invention provides a new strategy to isolate MSC from bone marrow mononuclear cells (BM-MNCs) by pooling BM-MNCs of multiple unrelated (third-party) bone marrow donors. The MSC preparation manufactured in accordance with the methodology of the invention is characterized by a stable proliferative capability and an increased immunosuppressive potential when compared to individual donor MSC preparations or a pool of individual MSCs generated from multiple donors. The MSCs prepared according to the invention are particularly useful for medical applications such as the treatment of graft-versus-host disease (GvHD) in recipients with hematopoietic stem cell transplants, patients with autoimmune disorders and as a cell-based therapy in regenerative medicine.
