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Anvendelse av (1S,2R)-enantiomeren av milnacipran for fremstillingen av et medikament
专利权人:
PIERRE FABRE MEDICAMENT
发明人:
DEREGNAUCOURT JEAN,GROSSE RICHARD
申请号:
NO20054228
公开号:
NO333987B1
申请日:
2005.09.12
申请国别(地区):
NO
年份:
2013
代理人:
摘要:
The use of a mixture of enantiomers of Milnacipran and/or its metabolites or salts, enriched in the dextrorotatory enantiomer F2695, is claimed in medicines for treating pathological disorders treated by the double inhibition of serotonin and noradrenaline recapture, while limiting the risk of cardiovascular disturbance. - ACTIVITY : Antidepressant Muscular-Gen Immunomodulator Analgesic Antiinflammatory Uropathic Antiaddictive. - MECHANISM OF ACTION : Serotonin inhibitor Noradrenaline recapture inhibitor. In tests used to determine the capture of noradrenaline and serotonin and the binding of paroxetine in rats, results showed that F2695 was twice as active as the racemic mixture (F2207) and 25 times as active as the levorotatory enantiomer (F2696) in the capture of noradrenaline, that F2695 was three times as active as F2207 and 12 times as active as F2696 in the capture of serotonin and that F2695 was twice as active as F2207 and 10 times as active as F2696 in binding paroxetine.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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