The invention relates to a nucleic acid construct encoding at least three RNA molecules comprising a double-stranded region, wherein the RNA molecules reduce influenza A virus replication in an animal cell and/or reduce production of infectious influenza A virus particles in an animal cell and/or reduce the expression of an influenza A virus polypeptide in an influenza A virus infected animal cell when compared to an isogenic influenza A virus infected animal cell lacking the RNA molecule, wherein the double-stranded regions comprise nucleotide sequences at least 95% identical to sequences selected from:(i) SEQ ID NO:7, SEQ ID NO:9 and SEQ ID NO:12,(ii) SEQ ID NO:6, SEQ ID NO:7 and SEQ ID NO:8, and(iii) SEQ ID NO:9, SEQ ID NO:13 and SEQ ID NO:15.
