DORAN, TIMOTH JAMES,MCKAY, JAMES CLIMIE,MOORE, ROBERT JOHN,LOWENTHAL, JOHN WILLIAM,TYACK, SCOTT GEOFFREY
申请号：
NZ59760108
公开号：
NZ597601A
申请日:
2008.05.16
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
Disclosed is a nucleic acid construct encoding three RNA molecules comprising a double stranded region, wherein the RNA molecules reduce influenza A virus replication in an animal cell and/or reduce production of infectious influenza A virus particles in an animal cell and/or reduce the expression of an influenza A virus polypeptide in an influenza A virus infected animal cell when compared to an isogenic influenza A virus infected animal cell lacking the RNA molecules, wherein the double-stranded regions comprise nucleotide sequences at least 95% identical to: (i) SEQ ID NO:9, SEQ ID NO:13 and SEQ ID NO:15.
