Rhodanine derivatives, a process for the preparation thereof and pharmaceutical composition containing the same

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专利权人:

Seong Eon Ryu

发明人:

Seong Eon Ryu,Seung Jun Kim,Dae Gwin Jeong,Sang Hyeup Lee,Suk Kyeong Jung,Hwan Mook Kim,Song Kyu Park,Ki Ho Lee,Chang Woo Lee,Joong-Kwon Choi,Jin Hee Ahn

申请号：

US12087474

公开号：

US08148541B2

申请日:

2006.12.08

申请国别(地区):

US

年份:

2012

代理人:

摘要：

Disclosed herein are rhodanine derivatives, a method for the preparation thereof, and a pharmaceutical composition containing the same. The rhodanine derivatives have inhibitory activity against protein phosphatases (PPase) such as PTP1B, Prl-3, LAR, CD45, Cdc25A, Cdc25B, Cdc25C, Yop, PP1 and VHR, and can be applied for the prevention and treatment of PPase-caused diseases, including autoimmune diseases, diabetes, impaired glucose intolerance, insulin resistance, obesity, cancers, etc. when the inhibitory activity thereof is modulated.

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