COMPOSITIONS COMPRISING AN AP2-SPECIFIC ANTIBODY OR A FRAGMENT THEREOF FOR USE IN TREATING DIABETES, GLUCOSE INTOLERANCE OR OBESITY-INDUCED INSULIN RESISTANCE

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专利权人:

PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人:

GOKHAN S. HOTAMISLIGIL,HAIMING CAO

申请号：

PT10707783

公开号：

PT2403605E

申请日:

2010.03.05

申请国别(地区):

PT

年份:

2015

代理人:

摘要：

A method of reducing a symptom of a clinical disorder characterized by aberrantly elevated circulating aP2 is carried out by administering to a subject an inhibitor of secreted aP2, secretion of aP2, or a serum aP2 blocking agent. For example, glucose intolerance is reduced following administration of such an inhibitor or agent. Exemplary compositions inhibit cellular secretion of aP2 or bind to circulating aP2, thereby reducing the level or activity of aP2 in blood or serum.

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