DEUTERATED ANALOGS OF ETIFOXINE, THEIR DERIVATIVES AND USES THEREOF

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专利权人:

Gaba Therapeutics Inc.

发明人:

Dasse, Olivier

申请号：

AU2020201728

公开号：

AU2020201728A1

申请日:

2020.03.09

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

#$%^&*AU2020201728A120200326.pdf#####ABSTRACT This invention relates to deuterated analogs of etifoxine of Formula I, solvates, prodrugs, and pharmaceutically acceptable salts thereof, as well as to methods for their preparation and use, and to pharmaceutical compositions. x1x HN1IX12 X2 x HN D N O X2 X3 X2 X3 X3 CI 48WO 2016/154039 PCT/US2016/023231 2000 1800 1600 S A 1400 E 1200 1000 -4-Etifoxine -,-Example 1 400 2 004 0 2 4 6 8 10 121 Figure 1: Mean plasma concentration-time profiles of etifoxine and example 1 after a PO dose of 50 mg/kg in male Sprague-Dawley rats

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