MARTORELL, ANTHONY JAMES,ADAIKKAN, CHINNAKKARUPPAN,TSAI, LI-HUEI,BROWN, EMERY,IACCARINO, HANNAH
申请号：
CA3003183
公开号：
CA3003183A1
申请日:
2016.11.23
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present disclosure provides systems and methods for at least one of preventing, reducing, and treating a level of or change in at least one of amyloid-ß (?ß) peptide, C-terminal fragment-ß (ß-CTF), ß-secretase (BACEl), ?-secretase, neuroinflammation, and/or dementia (e.g., Alzheimer's disease or age-related decline) in a subject by inducing synchronized gamma oscillations in the brain of the subject using, for example, a stimulus-emitting device to emit a stimulus (e.g., light, sound, and/or haptic) at a frequency (e.g., about 40 Hz) that synchronously activates in vivo a specific cell type (e.g., fast-spiking-parvalbumin (FS-PV) immunoreactive interneurons) and/or brain region (e.g., a sensory cortex and/or hippocampus) of the subject.
