This invention relates to novel compounds that are substituted xanthinederivatives and pharmaceutically acceptablesalts thereof. For example, this invention relates to novel substitutedxanthine derivatives that are derivatives of pentoxifylline.This invention also provides compositions comprising one or more compounds ofthis invention and a carrier and the useof the disclosed compounds and compositions in methods of treating diseasesand conditions for which pentoxifylline and relatedcompounds are beneficial.