Craig J. Thomas,Douglas S. Auld,James Inglese,Amanda P. Skoumbourdis,Jian-Kang Jiang,Matthew B. Boxer
申请号：
US15076258
公开号：
US20160199370A1
申请日:
2016.03.21
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed are pyruvate kinase M2 activators, which are, bis sulfonamide piperazinyl compounds of Formula (I) and 2,4-disubstituted 4H-thieno[3,2-b]pyrrole-2-(substituted benzyl)pyridazin-3(2H)ones of Formula (II), wherein L and R1 to R16 are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer and anemia,
