Provided are MYC-reporters and MYC-reporter expression vectors having MYC-reporter activity. Also provided are cells containing MYC-reporters and/or MYC-reporter expression vectors as well as animals containing such cells and/or genetically modified to contain one or more MYC-reporters and/or expression vectors. Also provided are methods of screening, including methods of screening a candidate agent for MYC repression. The subject methods may, in some instances, employ one or more of the provided MYC-reporters, expression vectors, cells and/or transgenic animals.
