The present invention relates to a vaccine comprising at least one peptide consisting at least of the amino acid sequence (X3)mKDX2QLGX1 (SEQ ID NO: 99), wherein X1 is an amino acid residue selected from the group consisting of alanine, asparagines, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, serine, threonine, tyrosine and valine, X2 is an amino acid residue selected from the group consisting of alanine, arginine, histidine, isoleucine, leucine, lysine, methionine, threonine, tyrosine and valine. X3 is (X4)nANISX5 (SEQ ID NO: 100) or an N-terminal truncated fragment thereof consisting of 1 to 4 amino residues, X4 is VVASQLR (SEQ ID NO: 101) or an N-terminal truncated fragment thereof consisting of 1 to 6 amino acid residues, X5 is an amino acid residue selected from the group consisting of alanine, asparagines, glutamine, glutamic acid, histidine, arginine, isoleucine, lysine, methionine, serine and threonine, m is 0 or 1, and n is 0 or 1, wherein said at least one peptide is coupled or fused to a carrier comprising at least one T-cell epitope.本發明係關於一種疫苗,該疫苗包含至少一胜肽,該胜肽包含7~19個胺基酸殘基,且該胜肽之胺基酸序列係(X3)mKDX2QLGX1(如SEQ ID NO:99所示),其中,該X1係一胺基酸殘基,選自丙胺酸、天門冬醯胺、穀氨醯胺、甘胺酸、組安酸、異白胺酸、白胺酸、賴胺酸、甲硫胺酸、絲胺酸、蘇胺酸、酪胺酸及纈胺酸所組成之群組,該X2係一胺基酸殘基,選自丙胺酸、精胺酸、組胺酸、異白胺酸、白胺酸、賴胺酸、甲硫胺酸、蘇胺酸、酪胺酸及纈胺酸所組成之群組,該X3係為胺基酸序列(X4)nANISX5(如SEQ ID NO:100所示)或包含1~4個胺基酸殘基之該胺基酸序列胺基端缺失片段,該X4係為胺基酸序列VVASQLR(如SED ID NO:101所示)或包含1~6個胺基酸殘基之該胺基酸序列胺基端缺失片段,該X5係一胺基酸殘基,選自丙胺酸、天門冬胺酸、穀氨醯胺、穀胺酸、組胺酸、精胺酸、異白胺酸、賴胺酸、甲硫胺酸、絲胺酸、蘇胺酸所組成之群組,其中,m為0或1,且n為0或1,其中,該至少一胜肽係與一載體偶合或熔合,且該載體包含至少一T細胞抗原表位。
