STAFFLER, Günther,LANDLINGER, Christine,MATTNER, Frank
申请号：
ES13724587
公开号：
ES2647138T3
申请日:
2013.05.23
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Vaccine comprising at least one peptide consisting of 7 to 19 amino acid residues consisting of the amino acid sequence: (X3) mKDX2QLGX1 (SEQ ID No. 99), wherein X1 is an amino acid residue selected from the group consisting of in alanine, asparagine, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, serine, threonine, tyrosine and valine, X2 is an amino acid residue selected from the group consisting of alanine, arginine, histidine, isoleucine, leucine, lysine, methionine, threonine, tyrosine and valine, X3 is (X4) nANISX5 (SEQ ID No. 100) or a truncated fragment at the N-terminal end thereof consisting of 1 to 4 amino acid residues, X4 is VVASQLR (SEQ ID NO. 101) or a truncated fragment at the N-terminal end thereof consisting of 1 to 6 amino acid residues, X5 is an amino acid residue selected from the group consisting of alanine, asparagine, glutamine, glutamic acid, histidine, arginine, isoleucine lysine methionine, serine and threonine, m is 0 or 1, and n is 0 or 1, wherein said at least one peptide is coupled or fused to a carrier comprising at least one epitope of T lymphocytes.Vacuna que comprende por lo menos un péptido que consiste en 7 a 19 residuos aminoácidos que consiste en la secuencia de aminoácidos: (X3)mKDX2QLGX1 (SEC ID nº 99), en la que X1 es un residuo aminoácido seleccionado de entre el grupo que consiste en alanina, asparagina, glutamina, glicina, histidina, isoleucina, leucina, lisina, metionina, serina, treonina, tirosina y valina, X2 es un residuo aminoácido seleccionado de entre el grupo que consiste en alanina, arginina, histidina, isoleucina, leucina, lisina, metionina, treonina, tirosina y valina, X3 es (X4)nANISX5 (SEC ID nº 100) o un fragmento truncado en el extremo N-terminal del mismo que consiste en 1 a 4 residuos aminoácidos, X4 es VVASQLR (SEC ID nº 101) o un fragmento truncado en el extremo N-terminal del mismo que consiste en 1 a 6 residuos aminoácidos, X5 es un residuo aminoácido seleccionado de entre el
