ALEXANDER HEGMANS,BRUCE W. FENSKE,DAN J. TREPANIER,DARREN R. URE,DAVE MCGLADE,DAVID P. CZAJKOWSKI,MARK D. ABEL,SHIN SUGIYAMA
申请号：
BRPI0911709
公开号：
BRPI0911709A2
申请日:
2009.07.03
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The compounds of the present invention are non-immunosupressive cyclosporine analogue molecules that are able to bind cyclophilin. Said compounds include a modified side chain of amino acid I of cyclosporin A, consisting of an oxyalkyl having substituents R', R1 and R2, where R' is H or Acetyl； R1 is a saturated or unsaturated straight chain or branched aliphatic carbon chain； and R2 may be a hydrogen； a unsubstituted, N substituted or NN disubstituted amide； a N substituted or unsubstituted acyl protected amine； a carboxylic acid； a N substituted or unsubstituted amine； a nitrile； a ester； a ketone； a hydroxy, dihydroxy, trihydroxy or polyhydroxy alkyl； or a substituted or unsubstituted aryl.
