Alessandra Leda Valverde;Antoniana Ursine Krettli;Núbia Boechat;Marcus Vinicius Nora de Souza
发明人:
Núbia Boechat,Marcus Vinicius Nora de Souza,Alessandra Leda Valverde,Antoniana Ursine Krettli
申请号：
US13296155
公开号：
US20120129887A1
申请日:
2011.11.14
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention refers to new compounds represented by the general formula (I) where X is represented by the general formula (II) and Y is represented by the general formula (III). The relation X to Y may vary from 1:1 to 1:7. The radicals R1, R2, R3, R4, R5, and R6 in formula (II) are represented by: R1═H, CF3, CH3, OCH3, NH2, halogen； R2═H, CH3, NH2, halogen, NH—CHCH3(CH2)3N(C2H5)(CH2CH2OH), CH(OH)-2(C5H11N), NH—R7—N—(C2H5)2； R3═H, m-OC6H4CF3, NH2； R4═H, CH3, OCH3, NH2, halogen； R5═H, CH3, CF3, NH2, halogen； R6═H, CF3, CH3, NH2, halogen, NH—R8—N—(C2H5)2, NHCH(CH3)(CH2)3NH2； R7═(CH2)2, (CH2)3, CHCH3CH2, (CH2)4, (CH2)5, CHCH3(CH2)3, (CH2)6, (CH2)8, (CH2)10, (CH2)12； R8═CHCH3(CH2)3, CHCH3(CH2)CHCH3, (CH2)2, (CH2)3, (CH2)6, (CH2)3O(CH2)3. This invention also refers to a process of preparation of these compounds (formula I), and antiparasitic pharmaceutical compositions thereof.
