It is to be understood that the object of the present invention to provide a manufacturing method that can be compared with the conventional methods, to give a biologically ingestible material having a particle size of interest at low energy, the processing flow of the dispersed phase containing a pharmacologically active substance through independent pathways of the body, while maintaining the state of each independent, and the processed fluid continuous phase consisting of a dispersion solvent at least, corresponding to each phase, and capable of approaching to and separating from disposed to face have the processing surfaces, by mixing in a thin film fluid to be formed between the processing surfaces one of which rotates relative to the other components contained in the processed fluid in the dispersed phase has a particle size of at least the desired it becomes fine particles.従来の方法に比べ、低エネルギーで目的とする粒子径の生体摂取物を得ることができる製造方法を提供することを課題とするものであって、薬理活性物質を含有する分散相の被処理流動体と、少なくとも分散溶媒よりなる連続相の被処理流動体とを、各々独立した状態を保持したまま、それぞれの相に対応する独立した経路を通じて、対向して配設された近接・離反可能な処理用面をもつ、少なくとも一方が他方に対して回転する処理用面の間にできる薄膜流体中で混合することにより、分散相の被処理流動体に含まれた成分が所望の粒子径を有する微小粒子となる。
