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ОПОСРЕДОВАННОЕ PHKI ИНГИБИРОВАНИЕ Rho-КИНАЗЫ ДЛЯ ЛЕЧЕНИЯ ГЛАЗНЫХ НАРУШЕНИЙ
专利权人:
АЛЬКОН РИСЕРЧ, ЛТД.
发明人:
ЧАТТЕРТОН Джон Е.,КЛАРК Эббот Ф.
申请号:
RU2011124528
公开号:
RU2011124528A
申请日:
2011.06.16
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. mRNA Rho-kinase A method for reducing expression in a subject using interfering RNA targeted to a gene ROCK2 Rho-kinase, for treating eye diseases comprising: administering to the subject a composition comprising an effective amount of interfering RNA and a length of 19 to 49 nucleotides and a pharmaceutically acceptable carrier, wherein the interfering RNA comprising: a sense circuit nucleotides, antisense nucleotides and chain region of at least near-perfect complementarity continuous at least 19 nucleotides where the antisense strand in physics ologicheskih conditions hybridizes with a portion of mRNA corresponding to SEQ ID NO: 2, and comprises a region of at least near-perfect continuous complementarity of at least 19 nucleotides with the hybridizing portion of mRNA corresponding to or SEQ ID NO: 2, respectively, which thus reduces the expression mRNA Rho-kinazy.2. The method of claim 1, wherein the individual is a human and the human eye is present gipertenziya.3. The method of claim 1, wherein the individual is a human and human risk of developing ocular gipertenzii.4. The method of claim 1, wherein the composition is administered via topical, intravitreal, transscleral, periocular, conjunctival, subtenonovogo, intracameral, subretinal, subconjunctival, retrobulbar or vnutrikanaltsevoy vvedeniya.5 method. The method of claim 1, where the antisense strand is designed to target an mRNA corresponding to SEQ ID NO: 2 comprising nucleotide 1102, 1865, 2000, 2229, 2514, 2584, 2738, 3305, 4111, 4652, 5184, 5187, 5255, 5315, 5439, 5450, 5578, 5579, 5611, 5625, 5795, 6000, 6228, 6264, 584, 1337, 1678, 2773, 2814, 2941, 3357, 3398, 3481, 3633, 3644, 3645, 3767, 3836, 4023, 4097, 5202 or 5440.6. A method according to claim 1, further including1. Способ снижения экспрессии мРНК Rho-киназы у индивида с помощью интерферирующей РНК, нацеленной на ген ROCK2 Rho-киназы, для лечения глазных болезней, включающий:введение индивиду композиции, содержащей эффективное количество
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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