This invention relates to compounds, which are in general potentiators of antiinffective agents and inhibitors of bacterial efflux pumps in particular. These novel compounds i.e. substituted dihydronaphthalene derivatives and tetralin derivatives and/or their salts are useful against antibiotic-resistant microbial pathogens, for treating microbial infections by reducing the extrusion of a co-administered antimicrobial agent. This invention also provides processes for the preparation of such efflux pump inhibitors and their compositions with antiinffective agents and methods for treatment of microbial infections.
