ЭПГАР Джеймс М. (US),АРАСАППАН Ашок (US),БИФТУ Тесфайе (US),ЧЭНЬ Пин (US),ФЭН Даньцин (US),ГАЙДРИ Эрин (US),ХИКС Жаклин (US),КЕКЕДЖ Ахмет (US),ЛЕВИТТ Кеннет (US),ЛИ Бин (US),МАККРЭКЕН Трой (US),СЕБХАТ
申请号：
RU2015109706
公开号：
RU2015109706A
申请日:
2013.08.19
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A compound of structural formula I or a pharmaceutically acceptable salt thereof, gdeT selected from the group consisting of CR, N and N-oxide U is selected from the group consisting of CR, N and N-oxide V is selected from the group consisting of CR, N and N-oxide W is selected from the group consisting of CR, N and N-oxide, with the proviso that at least one of T, U, V and W represents N or N-oxide X is selected izgde CHyavlyaetsya each unsubstituted or substituted by 1 or 2 substituents selected from hydroxy, halogen, NH, Ci ^ alkyl, COH, COCalkila, COCalkila, phenyl and -CHfenila, NH and wherein each is unsubstituted or replaced ene 1 substituent selected from: Ci ^ alkyl, COH, COCalkila, COCalkila, phenyl and -CHfenila Y is selected izgde A is selected from: CH, NH, NCalkila, O and S, and wherein Y is unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from R Z is selected izi r and each independently selected from: wherein each CHyavlyaetsya unsubstituted or substituted with 1 or 2 substituents selected from halo, CF, -OH, -NH, -Calkila, -OCalkila, and -N -NHCalkila (Ci ^ alkyl) wherein each alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, tsiklogeteroalkenil, phenyl, aryl and heteroaryl is unsubstituted or substituted by 1 2, 3 or 4 substituents selected from R, provided that at least one and only one of R R c is selected from the group consisting of hydrogen, halogen, -CN, -CF, -Calkila, and -Calkenila -Calkinila r and R, each independently absent or selected from: R c is selected izkazhdy independently selected from the group consisting izgde CHyavlyaetsya each unsubstituted or substituted by 1 or 2 substituents selected from oxo, -OH, - (CH) OH, -CN, -NH, -NH (Ci ^ alkyl), -N (Ci ^ alkyl), -Calkila, -Calkila substituted with 1-5 OH, -Calkila, halogen, -CHF, -CHF, -CF, -COH, -COCalkila, -Ctsikloalkila, phenyl CHfenila, heteroaryl and CHgeteroa yl, and wherein alkyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, tsikloget
