One aspect provides a drug dispenser device comprising a housing； extending from the housing, an outlet for insertion into a body cavity of a patient； provided to the housing and moveable with respect thereto, a drug discharge device having a longitudinal axis and comprising a container for storing a drug formulation to be dispensed, a discharge mechanism and a discharge channel from the container for discharge of the drug formulation to the outlet； connecting to the container, a container collar connected to the discharge device； connecting to the container collar and moveable with respect thereto along the longitudinal axis of the drug discharge device； connecting to the container collar and moveable with respect thereto along the longitudinal axis of the drug discharge device, a transfer element including an actuating portion； provided to the housing, at least one finger operable member moveable to apply an actuating force to the actuating portion of the transfer element to move the transfer element from an initial position along the longitudinal axis in a first direction； provided to the container collar, a pre-load mechanism to prevent transfer of the actuating force to the container collar to move the drug discharge device along the longitudinal axis in the first direction to actuate the discharge mechanism until a pre-determined threshold force is overcome； and connecting the container collar with the transfer element, a biasing return mechanism acting to bias the transfer element along the longitudinal axis in a second direction to return the transfer element to its initial position.
