Daniel Ortwine;Kevin Hon Luen Lau;Anthony Estrada;Zhonghua Pei;Frederick Cohen;Philippe Bergeron;Michael F.T. Koehler;Coung Ly;Xianrui Zhao;Joseph P. Lyssikatos
发明人:
Philippe Bergeron,Frederick Cohen,Anthony Estrada,Michael F.T. Koehler,Kevin Hon Luen Lau,Coung Ly,Joseph P. Lyssikatos,Daniel Ortwine,Zhonghua Pei,Xianrui Zhao
申请号：
US13410246
公开号：
US20120165313A1
申请日:
2012.03.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed are compounds of Formula I, including steroisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).
