Daniel Ortwine;Kevin Hon Luen Lau;Anthony Estrada;Zhonghua Pei;Frederick Cohen;Philippe Bergeron;Cuong Ly;Xianrui Zhao;Michael F. T. Koehler;Joseph P. Lyssikatos
发明人:
Philippe Bergeron,Frederick Cohen,Anthony Estrada,Michael F. T. Koehler,Kevin Hon Luen Lau,Cuong Ly,Joseph P. Lyssikatos,Daniel Ortwine,Zhonghua Pei,Xianrui Zhao
申请号：
US12533935
公开号：
US08163763B2
申请日:
2009.07.31
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed are compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).
