#$%^&*AU2012241083A120121101.pdf#####C:NRPOnblDCC\DAR\4665661_.DOC-lI /1V2012 ABSTRACT R 0 R6 N R2(l) RO () R R4 0 N H2 N R40 R, H R, R3 There is described a new polymorphic form of 4-(7-Hydroxy-2-isopropyl-4-oxo-4Hquinazolin-3-yl)-benzonitrile having structural formula (B) and to a method of preparing it. There is further a process or method for the manufacture of a pharmaceutically active quinazolinone compounds of the formula (1), wherein the symbols have the meanings given in the description, said process comprising reacting a compound of the formula (11), wherein R4* is R1*-C(=O)- wherein R1* is independently selected from the group of meanings of R1 as defined for a compound of the formula (1) so that R1* and R1 are identical to or different from each other, or R4* is especially H, and R1 and R3, R5 and R6 are as defined for a compound of the formula (1), or a salt thereof, under simultaneous or sequential condensation and cyclisation conditions with an aniline compound of the formula (111), wherein R2 and m are as defined for a compound of the formula (1). Further reactions and related embodiments are also claimed and disclosed.
