DAE YOUNG HAN,HYUN BO SHIM,NAM HOON KWON,SUNGHOON KIM
申请号：
BR112019020166
公开号：
BR112019020166A2
申请日:
2018.03.27
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
the present invention reports to an antibody binding specifically to an n-terminal region of lysyl-trna synthetase which is exposed on the cell membrane and a use thereof and, more particularly, to an antibody having a certain complementary determining region (cdr) stipulated in the specification and binding specifically to an epitope including the sequence of seq id no: 97 in a lysyl-trna synthetase (krs) n-terminal, or a fragment thereof, a use of the antibody or a fragment thereof in metastasis suppression and cancer diagnosis , and a pharmaceutical composition for prevention or treatment of an immune cell migration-related disease. far superior in specific binding affinity to a krs n-terminal region exposed on the cell membrane, the antibody or fragments thereof according to the present invention are effective for cancer diagnosis, have anti-cancer and metastasis inhibition effects, and can be very useful for preventing or treating an immune cell migration-related disease.the present invention relates to an antibody binding specifically to an n-terminal region of lysyl-trna synthetase which is exposed on the cell membrane and a use thereof and, more particularly, to an antibody having a certain complementary determining region (cdr) stipulated in the specification and binding specifically to an epitope including the sequence of seq id no: 97 in a lysyl-trna synthetase (krs) n-terminal, or a fragment thereof, a use of the antibody or a fragment thereof in metastasis suppression and cancer diagnosis, and a pharmaceutical composition for prevention or treatment of an immune cell migration-related disease. far superior in specific binding affinity to a krs n-terminal region exposed on the cell membrane, the antibody or fragments thereof according to the present invention are effective for cancer diagnosis, have anti-cancer and metastasis inhibition effects, and can be very useful for preventing or treating an immune cell migration-related disease.
