HOLTZE, Christian;SHUM, Ho, Cheung;PRESIDENT AND FELLOWS OF HARVARD COLLEGE;BASF SE;WEITZ, David, A.;SUN, Bingjie;ZHAO, Yuanjin
发明人:
WEITZ, David, A.,SHUM, Ho, Cheung,ZHAO, Yuanjin,SUN, Bingjie,HOLTZE, Christian
申请号：
USUS2012/050916
公开号：
WO2013/032709A3
申请日:
2012.08.15
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention generally relates to particles, including particles for drug delivery and other applications. Certain aspects of the invention are generally directed to particles comprising a shell and an interior at least partially contained by the shell. In some embodiments, the particles may be treated to enhance the containment of the interior, for example to reduce transport of an agent into or out of the interior. Such particles may exhibit increased ability to encapsulate agents and/or increased storage life (e.g., due to reduced leakage). For instance, in certain embodiments, any defects, such as cracks, pores, etc. within the shell may be sealed or otherwise treated to reduce transport therethrough, for example, with a solid. In some embodiments, for instance, a first reactant in the interior of a particle may come into contact with a second reactant outside of the particle to form a solid, or other suitable product. The shell may also be treated, e.g., at a later point in time, to cause release of an agent contained within the interior, in certain aspects. For example, the shell may be heated to cause the release of the agent from the particle, or the shell may be exposed to chemical or enzymatic degradation, or a change in osmolarity, to cause release of an agent. Still other aspects of the present invention are generally directed to methods of making or using such particles, kits or devices including such particles, or the like.La présente invention concerne de façon générale des particules, notamment des particules destinées à l'administration de médicaments et à d'autres applications. Certain aspects de l'invention visent de façon générale des particules comportant une coque et un intérieur au moins partiellement contenu par la coque. Dans certains modes de réalisation, les particules peuvent être traitées pour renforcer le confinement de l'intérieur, par exemple pour réduire le transport d'un agent vers ou depuis l'intérieur. De telles particule
