KWON, TAEK KWAN,权宅灌,權宅灌,CHOI, YOUNG KEUN,崔荣根,崔榮根,YAN, XUE WEN,闰学文,閏學文,WANG, ZHAO ZHEN,王兆珍,KIM, YONG IL,金用镒,金用鎰,PARK, JAE HYUN,朴宰贤,朴宰賢,WOO, JONG SOO,禹锺守,禹鍾守
申请号：
TW103144296
公开号：
TW201609184A
申请日:
2014.12.18
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present invention relates to a liquid formulation comprising a solubilizer and montelukast or pharmaceutically acceptable salt thereof in a solution state as an active ingredient, and a method for preparing same. The liquid formulation of the present invention allows montelukast or pharmaceutically acceptable salt thereof to be substantially dissolved and present in a solution state, thereby preventing decrease of dissolution over time and increasing its bioavailability. In addition, because the liquid formulation of the present invention shows superior stability, taste and flavor, its medication compliance can be enhanced and it can be effectively utilized for asthma and allergic rhinitis patients.本發明關於一包含一助溶劑以及作為一活性成分之於一溶液狀態中之蒙特魯卡斯特或其藥學上可接受之鹽類的液體調配物，及其製備方法。本發明之液體調配物允許蒙特魯卡斯特或其藥學上可接受之鹽類被實質地溶解並且存在於一溶液狀態中，藉此防止溶解隨著時間之降低並且增加其生物可利用性。此外，因本發明之液體調配物表現出優良的穩定性、味道及口味，其服藥順從性可被增加且其可被有效地使用在氣喘及過敏性鼻炎病患的身上。
