SHARPLESS NORMAN E,TORRICE CHAD D,RAMSEY MATTHEW R,JOHNSON SOREN,BELL JESSICA F
申请号：
IN2355/DELNP/2011
公开号：
IN2011DN02355A
申请日:
2011.03.30
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
Methods for reducing or preventing the effects of ionizing radiation in healthy cells are provided. The methods relate to the use of selective cyclin-dependent kinase (CDK) 4/6 inhibitors to induce transient quiescence in CDK4/6 dependent cells, such as hematopoietic stem cells and/or hematopoietic progenitor cells. Radioprotection can be effected in mammals by treatment with selective CDK4/6 inhibitor compounds either before, at the same time as, or after exposure to the ionizing radiation.
