Norman Edward Sharpless,Jay Copeland Strum,John Emerson Bisi,Patrick Joseph Roberts,Matthew R. Ramsey
申请号：
US14495381
公开号：
US20150111896A1
申请日:
2014.09.24
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Methods for reducing or preventing the effects of cytotoxic compounds in healthy cells are provided. The methods relate to the use of selective cyclin-dependent kinase (CDK) 4/6 inhibitors to induce transient quiescence in CDK4/6 dependent cells, such as hematopoietic stem cells and/or hematopoietic progenitor cells. Also described is a method of selecting compounds for reducing or preventing the effects of cytotoxic agents compounds in healthy cells.
