SUENOBU NORIKO JAPAN,KONDO CHIHIRO JAPAN,YAMASAKI TAKASHI JAPAN
申请号：
IN4090/CHENP/2011
公开号：
IN2011CN04090A
申请日:
2011.06.13
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
Provided are anti-wrinkle agents having a novel scaffold that is suitable as components for external skin preparations such as cosmetics. The anti-wrinkle agents comprise compounds represented by general formula (1), stereoisomers thereof, or pharmacologically acceptable salts thereof. Said anti-wrinkle agents have excellent efficacy in improving wrinkles and sagging that are caused by skin aging with increased age or occur as a result of photoaging due to ultraviolet rays exposure. In the formula, R1 represents a hydrogen atom or a 1 to 8 carbon straight or branched alkyl group. R2 represents -SH, -SO3H, -S-S-X1, -S-X2, -SO-X3, - SO2-X4, -SO2-NY1-X5 or -SO2-NY2-Y3. XiX5 independently are hydrogen atoms or 1 to 8 carbon aliphatic hydrocarbon groups or 5 to 12 carbon aromatic moiety wherein carbon atoms may be substituted with heteroatoms. Y1 to Y3 independently represent hydrogen atoms or 1 to 8 carbon linear or branched alkyl groups. R3 represents a hydrogen atom or acyl group having a 1 to 8 carbon straight or branched alkyl chain. R4 represents a 5 to 12 carbon aromatic group or polycyclic condensed aromatic group that may have unsubstituted or substituted groups. mrepresents an integer 0-3 and n represents an integer 1 or 2.
