Xun Suo,Xiaojia Wang,Xianyong Liu,Tuanyuan Shi,Lili Hao,Wenchao Yan,Hongyan Wang,Jianan Li
申请号：
US12593851
公开号：
US08142771B2
申请日:
2008.03.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides a novel use of coccidian, specifically relates to the use of coccidian as a vaccine live vector. The present invention further provides a live vaccine with coccidian as a vector, which is transgenic coccidian capable of expressing exogenous protein or stably transfected coccidian that contain expression vector and can express exogenous coccidian. The present coccidian vector live vaccine can induce organisms to simultaneously generate protective humoral and cellular immune responses (including the mucosal immune response), as well as generate memory responses, which can be readily carried out and has stable effect and high biological safety without generating immune tolerance.
