The present invention provides a new use of coccidia, specifically relates to the use of coccidia as a live vaccine vector. The present invention further provides live vector vaccines, which are transgenic coccidia or stably transfected coccidia capable of expressing exogenous proteins. The present live coccidia vector vaccine can stimulate strong humoral, cellular and mucosal immune responses in hosts, as well as generate memory responses. The present invention can be readily carried out and has stable effect and high biological safety without generating immune tolerance.
