The Cleveland Clinic Foundation;The Johns Hopkins University
发明人:
Sridevi SARMA,Adam LI,Jorge GONZALEZ-MARTINEZ
申请号：
US16348766
公开号：
US20190290185A1
申请日:
2017.11.10
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A method of identifying an epileptogenic zone of a subjects brain includes: receiving a plurality N of physiological brain signals that extend over a duration, each of the plurality N of physiological brain signals acquired from the subjects brain； calculating within a time window a state transition matrix based on at least a portion of each of the plurality N of physiological brain signals, wherein the state transition matrix is a linear time invariant model of a network of N nodes corresponding to the plurality N of physiological brain signals； calculating a minimum norm of a perturbation on the state transition matrix that causes the network to transition from a stable state to an unstable state； and assigning a fragility metric to each of the plurality N of physiological brain signals based on the minimum norm of the perturbation for that physiological brain signal.
