PROCÉDÉ POUR LE DIAGNOSTIC DE LA MALADIE D'ALZHEIMER ET DE LA DÉGÉNÉRESCENCE LOBAIRE FRONTOTEMPORALE, AGENT DIAGNOSTIQUE, AGENT THÉRAPEUTIQUE, ET PROCÉDÉ DE DÉPISTAGE UTILISANT LESDITS AGENTS
National University Corporation Tokyo Medical and Dental University
发明人:
申请号：
EP14875056.5
公开号：
EP3088898A4
申请日:
2014.12.25
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
It has been revealed that, from a pre-onset stage of Alzheimer's disease, enhancement of phosphorylations of MARCKS and the like causes abnormal spine formation or the like, consequently developing the disease. Moreover, it has also been revealed that the phosphorylations of MARCKS and the like are caused by PKC and the like, and further that b-raf is involved in the phosphorylation of a tau protein important for the progression of Alzheimer's disease. Thus, these proteins have been found to be target molecules useful in the diagnosis and treatment of Alzheimer's disease. In addition, it has also been revealed that, in a pre-onset stage of frontotemporal lobar degeneration also, b-RAF phosphorylation enhancement causes a decrease in the number of spines and the like, consequently developing the disease. Thus, b-RAF has been found to be a target molecule useful in the diagnosis and treatment of frontotemporal lobar degeneration.
