PAN, CLARK,ZHENG, XIAOYANG,MILLER, ROBERT J.,KUTZKO, JOSEPH,ZHU, YUNXIANG,PATTERSON, DUNCAN,PEER, ANDREAS,KONOWICZ, PAUL A.,AVILA, LUIS Z.,STEFANO, JAMES E,REARDON, MICHAEL R.,HARRAHY, JOHN,ZHOU, QUN
申请号：
ES12160009
公开号：
ES2534056T3
申请日:
2009.12.11
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A method of preparing a compound having Formula VIIA: ** Formula ** wherein: R1 is selected from hydrogen, hydroxyl, an alkyl group with 1 to 4 carbons, optionally substituted, phosphate, sulfate, -OR7, a protecting group , and a saccharide； R2, R3, R4 and R5 are each independently selected from hydrogen, sulfate, hydroxyl, -OR8, a protecting group and a saccharide； R6 is selected from hydrogen, hydroxy, carboxyl, alkoxycarbonyl, amino, amide, alkylamino, aminoalkyl, aminoxy, hydrazide, hydrazine, optionally substituted alkenyl and optionally substituted C2-C6 alkyl； R7 and R8 are each independently selected from acetyl and an optionally substituted alkyl group with 1 to 4 carbons； and n is an integer from 1 to 10； which comprises: a) treating a compound having Formula VIIIA: ** Formula ** wherein: R1 to R5 are as defined above； and R9 and R10 are chosen from hydrogen and hydroxyl, so that when one of R9 and R10 is hydroxyl, the other is hydrogen； with a compound having the Formula R11R12 (Sn>； = O) to form a compound having the Formula IXA: wherein: R1 to R5 are as defined above； and R11 and R12 are each independently selected from unsubstituted alkyl, or R11 and R12, taken together, are chosen from unsubstituted alkylene； and b) treating the compound of Formula IXA, optionally in the presence of a metal halide, with a compound having the Formula R6- (CH2) n-L, wherein: R6 and n are as defined above； and L is a halogen； to form the compound of Formula VIIAUn método de preparar un compuesto que tiene la Fórmula VIIA: **Fórmula** en donde: R1 se elige de hidrógeno, hidroxilo, un grupo alquilo con 1 a 4 carbonos, opcionalmente sustituido, fosfato, sulfato, -OR7, un grupo protector, y un sacárido； R2, R3, R4 y R5 se eligen, cada uno independientemente, de hidrógeno, sulfato, hidroxilo, -OR8, un grupo protector y un sacárido； R6 se elige de hidrógeno, hidroxilo, carboxilo, alcoxicarbonilo, amino, amida, alquilamino, aminoalquilo, aminoxi, hidrazida, hidrazina, alqueni
